Tell your specialist about next condition:

• heart disease

• congestive heart failure or ;

• a history of stroke

• fluid retention;

• a history of heart attack; or

• a history of bladder cancer;

• liver disease.

You should not use this drug  if you are in a state of diabetic ketoacidosis, if you have allergic reaction to pioglitazone, if you have active bladder cancer,if you have severe heart failure.

It  is an oral diabetes drug . Actos helps control blood sugar levels and Actos is for patients with type second diabetes.

This drug is sometimes used in combination with other medications , such as insulin , but it is not for treating type first diabetes.

Medicine which that can lower blood sugar,if you take its with Actos such as:

• probenecid (Benemid);

• insulin;

• aspirin or other salicylates (including Pepto-Bismol);

• some NSAIDs (nonsteroidal anti-inflammatory drugs);

• blood or  heart  pressure medication (Zestril,Altace,Accupril,  Lotensin,  Vasotec,Prinivil and others);

• sulfa drugs (Gantanol,Bactrim,  SMX-TMP, Septra,Gantrisin,  and others);

• MAOI (a monoamine oxidase inhibitor); or

• a blood thinner (Coumadin, warfarin,  and others);

•  diabetes medications: metformin (Glucophage),rosiglitazone (Avandia), acarbose (Precose),  miglitol (Glyset).

Tell your provider about all other drugs you use,such as:

• delavirdine (Rescriptor);

• bosentan (Tracleer);

• gemfibrozil (Lopid);

• digoxin (Lanoxin);

• vancomycin ( Lyphocin,Vancocin);

• midazolam (Versed);

• trimethoprim (Primsol,Proloprim,  Cotrim,Bactrim,  Septra);

• tolbutamide (Orinase);

• seizure medication such as phenytoin (Dilantin), carbamazepine (Equetro, Carbatrol,  Tegretol),primidone (Mysoline), phenobarbital (Solfoton),  and others.

• morphine (MS Contin,Kadian,  Oramorph);

• furosemide (Lasix), triamterene (Dyrenium) or amiloride (Midamor);

• ranitidine (Zantac) or cimetidine (Tagamet);

•  ketoconazole (Nizoral) or fluconazole (Diflucan);

• nifedipine (Procardia, Nifedical ) or nicardipine (Cardene);

• procainamide (Procan, Procanbid, Pronestyl), quinine (Qualaquin) or quinidine (Quin-G) ;

• a non-steroidal anti-inflammatory drug (NSAID) such as flurbiprofen (Ansaid),celecoxib (Celebrex),  ibuprofen (Motrin, Advil), mefenamic acid (Ponstel), piroxicam (Feldene) or  indomethacin (Indocin);

• rifampin (Rifadin,Rifamate, Rifater ) or rifapentine (Priftin);

Less serious  side effects may be the next:

• cold symptoms such as  sneezing, stuffy nose, sore throat, cough;

• gradual weight gain;

• headache;

• tooth problems;

• back pain; or

• muscle pain.

Allergic reaction:

-hives;

-difficulty breathing;

-swelling of your face, lips, tongue, or throat.

Serious side effects:

• blood in your urine, stomach pain ;

• painful urination;

•  rapid weight gain or swelling;

• general ill feeling, chest pain ;

• feeling short of breath;

•  yellowing of the eyes or skin, upper stomach pain, nausea,itching, dark urine, loss of appetite, clay-colored stools ;

• weakness, pale skin, easy bleeding or bruising;

• blurred vision;

• urinating more than usual

• increased hunger or thirst.

Consult with your doctor, if you have any allergic reaction to Actos, call your doctor and stop using this drug. Also don’t use this drug  if you have active bladder cancer,  if you are in a state of diabetic ketoacidosis, if you have severe heart failure.

The next condition may be serious, because if you have its call your doctor:

•  congestive heart failure or  heart disease;

• fluid retention;

• liver disease;

• a history of bladder cancer;

•  a heart attack or  history of stroke.